G-protein coupled receptors ?

1.    G-protein coupled receptor are type of receptor are types of receptor present on different kind of cell, this receptor have complex G-protein associated with its cytoplasmic tail.

2.    G- protein receptor, are the protein which have the ability to exchange from GDP to GTP

3.    Most of the G-protein are in active from when they are bound to GTP and inactive when they are bound to GDP.

4.    One of the examples of such G-protein couple is epinaflen.

5.    In this case there is a receptor for epinaflene on the cell surface and a complex of there G- protein at cytoplasmic region.

6.    This protein are α, β, γ, G-protein.

7.    When signal molecule binds to the receptor the α G-protein dissociate from β and γ with the exchange of GDP-GTP.

8.    This dissociated GTP bound α-G protein then binds to mem-bound enzyme adenylate cyclase.

9.    Adenylase cyclase is inactive without associated of GTP bound α-G protein.

10.      When α-G protein bound to, it gets activated

11.      After activation it catalases reaction in which ATP is converted into cyclic AMP.

12.      Eventually GTP of α-G protein is hydrolyzed GDP. And due to this α-G protein dissociated from adenylate cyclase.

13.      After this α-G protein rebound γ and β complex and ready for next cycle.